News | Radiation Therapy | November 02, 2021

DCISionRT and its Response Subtype Identifies DCIS Patients with Unacceptably Elevated Risk of Local Recurrence after Breast Conserving Surgery and Radiation Therapy

Data presented demonstrates use of DCISionRT and its response subtype (Rst) was able to identify women with ductal carcinoma in situ (DCIS)  (Stage 0 breast cancer) who remain at an elevated risk of recurrence despite receiving breast conserving surgery (BCS) and radiation therapy (RT).

November 2, 2021 — Prelude Corporation, a leader in molecular diagnostics and precision medicine for early-stage breast cancer, presented data in an oral scientific session presentation at the American Society for Radiation Oncology (ASTRO) 63rd Annual Meeting held Oct.24 – 27, 2021, at McCormick Place West in Chicago, IL. Data presented demonstrates use of DCISionRT and its response subtype (Rst) was able to identify women with ductal carcinoma in situ (DCIS) (Stage 0 breast cancer) who remain at an elevated risk of recurrence despite receiving breast conserving surgery (BCS) and radiation therapy (RT).

ASTRO Presentation #513, titled Biosignatures to Optimize Adjuvant Radiation Therapy Use in Patients with DCIS with High Risk Clinicopathologic Features examined 485 women diagnosed with DCIS and treated with BCS, with or without RT. The study examined the utility of DCISionRT and its response subtype by classifying these women into three risk groups:  Low Risk—those who could safely omit RT, Elevated Risk with Good Rst—those who benefited significantly from RT, and Elevated Risk with Poor Rst—those with increased recurrence rates post-treatment with BCS and RT who may need alternative therapeutic strategies beyond standard treatment.

“Women classified into the Elevated Risk group with Good Rst by DCISionRT had significant benefit from adjuvant radiation, with 10-year risk reduced to 5%,” said Frank Vicini, M.D., Radiation Oncologist at GenesisCare, member of NRG Oncology, and presenter of the study. “However, patients classified into the Elevated Risk group with a Poor Rst had a 25% risk of recurrence at 10 years despite being treated with both BCS and adjuvant RT.”

“For the first time, this study demonstrates the ability to identify patients who have high recurrence risk after BCS and RT,” said study investigator Chirag Shah, M.D., Director of Breast Radiation Oncology, Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. “This additional information is critical and will help guide treatment decisions, since Elevated Risk with Poor Rst patients may benefit from supplemental therapeutic strategies.”

“Our ongoing clinical studies reinforce the medical need for personalized treatment decisions for women upon a DCIS diagnosis,” says Dan Forche, President and CEO of PreludeDx.  “Our widely accessible DCISionRT test gives physicians and their patients the utmost confidence in their DCIS treatment decisions. As we continue the development of our precision testing pipeline, including our response subtype biosignature, we look forward to delivering predictive  tools that positively impact treatment decisions and provide peace of mind to even more patients with early-stage breast cancer.”

For more information: www.preludedx.com


Related Content

News

Aug. 5, 2024 — Researchers from The University of Texas MD Anderson Cancer Center have demonstrated that adding ...

Time August 09, 2024
arrow
News | PET-CT

July 31, 2024 — In a head-to-head comparison with FDG PET/CT, FDG PET/MRI demonstrated comparable or superior diagnostic ...

Time July 31, 2024
arrow
News | Radiology Business

July 31, 2024 — The American Registry of Radiologic Technologists (ARRT) announced the three Registered Technologists (R ...

Time July 31, 2024
arrow
Feature | Radiation Oncology | By Christine Book

News emerging from several leading organizations and vendors in the radiation therapy arena came in at a fast pace in ...

Time July 30, 2024
arrow
News | Breast Imaging

July 29, 2024 — Lunit, a leading provider of AI-powered solutions for cancer diagnostics and therapeutics, announced the ...

Time July 29, 2024
arrow
News | Breast Imaging

July 29, 2024 — iCAD, Inc., a global leader in clinically proven AI-powered cancer detection solutions, announced a ...

Time July 29, 2024
arrow
News | Radiology Business

July 25, 2024 — The radiology gender gap is decreasing, but there remains work to be done, according to an editorial ...

Time July 25, 2024
arrow
News | Radiopharmaceuticals and Tracers

July 24, 2024 — Telix Pharmaceuticals Limited announced that the United States (U.S.) Food and Drug Administration (FDA) ...

Time July 24, 2024
arrow
Videos | Breast Imaging

Don't miss ITN's latest "One on One" video interview with AAWR Past President and American College of Radiology (ACR) ...

Time July 24, 2024
arrow
News | RSNA

July 23, 2024 — Professional registration is open for RSNA 2024, the world’s largest radiology forum. This year’s theme ...

Time July 23, 2024
arrow
Subscribe Now