ProHance is a macrocyclic, nonionic, gadolinium-based magnetic resonance imaging (MRI) contrast agent designed for use in MRI in adults and children over two years of age to visualize lesions with abnormal vascularity in the brain (intracranial lesions), spine and associated tissues. ProHance is also indicated for use in MRI in adults to visualize lesions in the head and neck.
The agent reportedly has the highest thermodynamic stability constant and lowest osmolality of all gadolinium contrast agents in its class.
The clinical experience with ProHance exceeds 10 million doses safely administered worldwide, according to the company.
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