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I recently attended the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) in San Diego. This year’s meeting included a celebration of the 40th anniversary of FDG, a radiopharmaceutical used in the medical imaging modality positron emission tomography (PET) that has had a pervasive impact on molecular imaging. At the opening plenary session, the Henry Wagner Lecture was given by Joanna Fowler, Ph.D., Brookhaven National Laboratory, on “Designing and Synthesizing FDG for the First Human Studies in 1976.” Signage throughout the convention center featured FDG pioneers and quotes on FDG by past presidents.