Countries across the globe are struggling to combat issues such as escalating healthcare costs, poor or inconsistent quality of healthcare, rapid expansion in healthcare insurance and changing healthcare reform mandates. Growing consumerism, globalization, changing demographics and lifestyles, and growing incidences of diseases that are expensive to treat further exacerbate these. Resolving these issues is a daunting task faced by healthcare stakeholders, highlighting the need for proactive, collaborative and systemic models. Several initiatives and healthcare reforms have been developed in order to support the adoption and implementation of clinical decision support software (CDSS) solutions.