Biopharmaceuticals Inc. announced the first subject has been enrolled in its NAV4694 global, pivotal Phase 3 clinical trial. The trial will assess the safety and efficacy of NAV4694, an investigational positron emission tomography (PET) imaging agent, in detecting cerebral ?-amyloid in end-of-life subjects with and without the diagnosis of dementia. The study will examine the effectiveness of NAV4694 in detecting the presence or absence of ?-amyloid deposition in the brain by directly correlating the PET image findings during life with those of the brain tissue upon autopsy after death.